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CATEGORIES:Lectures & Talks
DESCRIPTION:Join us to hear from Andrew Borovik about his research at the U
 niversity of California\, Irvine!\n\nAbstract: The oxidation of substrates 
 via the cleavage of thermodynamically strong C–H bonds is an essential part
  of mammalian metabolism. These reactions are predominantly carried out by 
 enzymes that produce high valent metal–oxido species\, which are directly r
 esponsible for cleaving the C–H bonds. While much is known about the identi
 ty of these transient intermediates\, the mechanistic factors that enable m
 etal–oxido species to accomplish such difficult transformations are still i
 ncomplete. For synthetic metal–oxido species\, C–H bond cleavage is often m
 echanistically described as synchronous proton coupled electron transfer (P
 CET). However\, data have emerged that suggest the basicity of the M– oxido
  unit is the key determinant in achieving enzymatic function\, thus requiri
 ng alternative mechanisms whereby proton transfer (PT) has a more dominate 
 role than electron transfer (ET). \n\nThis presentation will describe our r
 esearch to gain mechanistic insights into how metal–oxido complexes activat
 e C–H bonds. We have used a series of well-characterized Mn(III)– and M(IV)
 –oxido complexes to show that PT has a dominate role in the activation proc
 esses. Our experimental findings led to a proposed PCET mechanism with asyn
 chronous transition states that is dominated by PT. To support this premise
 \, a new semi-empirical free energy analysis was developed that can predict
  the relative contributions of PT and ET for a given set of substrates. The
 se findings underscore why the basicity of M–oxido units needs to be consid
 ered in C–H functionalization.   \n \n\nHost: Brandon Barnett | brandon.bar
 nett@rochester.edu
DTEND:20250430T170000Z
DTSTAMP:20260414T000439Z
DTSTART:20250430T160000Z
GEO:43.125274;-77.630811
LOCATION:Hutchison Hall\, 140
SEQUENCE:0
SUMMARY:Chemistry Colloquium: “Biological C-H Bond Activation”
UID:tag:localist.com\,2008:EventInstance_49294064148306
URL:https://events.rochester.edu/event/chemistry-colloquium-biological-c-h-
 bond-activation
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