Join us to hear Marcey L. Waters from UNC Chapel Hill discuss her research!

Abstract: Post-translational modifications (PTMs) in histone proteins, including lysine methylation and acylation, regulate gene expression through recruitment of reader proteins to the nucleosome. Dysregulation of these events is prevalent in a wide range of diseases, such that there is much interest in characterizing these modifications and their binding partners as well as developing inhibitors for these protein-protein interactions. I will discuss mechanistic studies of the factors that contribute to these PTM-mediated protein-protein interactions using a combination of high-throughput mechanistic screening, genetic code expansion, and investigation of PTM-isosteres and how this has led to novel approaches to inhibit them.