The University of Rochester School of Medicine and Dentistry,
The Department of Neuroscience, and the Del Monte Institute for Neuroscience
Jeff Kuret, Ph.D.
Professor of Biological Cenistry and Pharmacology
Co-Director of OSU Biophysics Graduate Program
Ohio State Univ.
Tau Protein and Alzheimer's Disease
This seminar will focus on two problems associated with neurofibrillary lesion formation in tauopathic neurodegenerative disorders such as Alzheimer’s disease (AD). First, with respect to vulnerable neuron populations, recent discoveries point to small tau aggregates as being especially important for prion-like spread and toxicity. But authentic neurofibrillary lesions are characterized by the accumulation of long filamentous aggregates. Indeed, neither the size distributions of tau aggregates in authentic disease nor in model systems conform to current understanding of aggregation kinetics. Here I will present evidence for a new secondary process in tau aggregation that, together with fragmentation, rationalizes tau filament length distribution. Second, with respect to seemingly invulnerable neuron populations, I will discuss the absence of tau filament formation as an avenue to identifying molecular signatures potentially associated with AD neuroprotection. The approach leverages gene expression analysis in affected and unaffected brain regions. Preliminary results from this approach will be presented.
Thursday, November 15, 2018 at 4:00pm to 5:00pm
School of Medicine and Dentistry, K-307 (3-6408)
415 Elmwood Ave, Rochester, NY 14642