Olaf Kutsch, Ph.D., Professor- Department of Medicine, University of Alabama at Birmingham, will present “Comprehensive Network Analysis Reveals Host Cell Targets That Control Latent HIV-1 Infection.”
Hosted by the Virology Faculty Search Committee and sponsored by the T32AI049815, “Training in HIV Replication and Pathogenesis."
Seminar Abstract: A growing body of evidence suggests that latent HIV-1 infection events are controlled by functional modifications to the host-cell signaling network that restrict HIV-1 expression and quench the host-cell response to stimulation. We demonstrate that these network modifications can be detailed at high resolution by the integration of data derived from several high-information content generating methods such as kinome analysis, Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) analysis and transcription factor binding site predictions. Given the complexity of the revealed host cell control network, our data suggest that single drug therapies aimed at eradicating the HIV-1 reservoir are prone to fail.
Monday, September 24, 2018 at 12:00pm to 1:00pm
School of Medicine and Dentistry, Upper Auditorium (3-7619)
415 Elmwood Ave, Rochester, NY 14642