Embedding Pragmatic Trials into Clinical Care: Can Implementation Methods Enhance Comparative Effectiveness Research

Pragmatic trials embedded with the people and systems of care are highly efficient at generating evidence for comparative effectiveness questions that can inform care. To provide a meaningful answer, embedded pragmatic trials depend on clinicians to adhere to the intervention assigned by randomization, and barriers to adherence are a threat to the informativeness of the trial overall. Clinical trialists can use implementation science tools and frameworks during the trial to optimize adherence and ensure the informativeness of the trial. The methods to do this are not established. This presentation by Kevin Seitz, MD, MSCR, from Vanderbilt University Medical Center will describe a study assessing clinician-level contextual factors relevant to adherence in a pragmatic trial of ventilator modes for critically ill adults and will propose a systematic approach to assessing and intervening on barriers across with implementation strategies that should be used to guide the conduct of multi-center trials embedded into clinical care.

This presentation will be via Zoom.

This event, hosted by the Trial Innovation Network, is available to the University of Rochester community via the UR Clinical and Translational Science Institute.