Nicholas Mantis, Ph.D., Associate Professor, Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, will present “Secretory IgA and Intestinal Immunity to Vibrio cholerae.”
Michelle Dziejman will host.
Talk is sponsored by the T32AI118689, “Infection and Immunity: The Pathogenesis of Host-Microbe Interactions”
Seminar Abstract: A long term goal of my laboratory at the Wadsworth Center is to develop more effective mucosal vaccines to control enteric diseases like salmonella and cholera. This seminar will focus on our current understanding of how secretory IgA limit the ability of Vibrio cholerae to colonize the intestinal epithelium and how this information impacts vaccine design. I will present evidence that protective antibodies are potent inhibitors of bacterial motility and trigger a form of outer membrane stress and exopolysaccharide expression. A genetic screen for V. cholerae “escape” mutants that were able to “swim” in the presence of normally inhibitory amounts of antibody identified an inner membrane mechanosensitive channel implicated in sensing changes in outer membrane architecture and possibly modulating interactions with the intestinal epithelium.
Monday, October 1, 2018 at 12:00pm to 1:00pm
School of Medicine and Dentistry, Upper Adolph Auditorium (3-7619)
415 Elmwood Ave, Rochester, NY 14642