'Regulation of CD8+ T cell Metabolism in the Tumor Microenvironment' Presented by Andrea Amitrano, Graduate Student; Pathology PhD Candidate. Chimeric antigen receptor T cell (CAR-T cell) therapy has demonstrated tremendous success in eradicating hematological malignancies; however, CAR-T cells exhibit limited clinical success in solid tumors. This is in part due to significant metabolic challenges presented in the tumor microenvironment (TME). To specifically augment CD8+ T cell mitochondrial metabolism and cell migration in the TME, we developed a genetically encoded photoactivatable proton pump that is expressed in the inner mitochondrial membrane ("OptoMito-On”). Our study demonstrates the development of a novel tool to increase mitochondrial ATP production in CD8+ T cells in the hopes of improving CAR-T cell therapies for solid malignancies.
Monday, October 19 at 12:00pm to 1:00pmVirtual Event