Immature low-density neutrophils as mediators of pyoderma gangrenosum and inflammatory bowel disease pathogenesis

Pyoderma gangrenosum (PG) is a debilitating skin condition characterized by deep, pus- filled, non-healing ulcers packed with neutrophils and is a common extraintestinal manifestation of inflammatory bowel disease (IBD). Strikingly, ~40% of people with an initial presentation of PG go on to be also diagnosed with IBD, suggesting that both diseases have common factors driving their pathogenesis. The molecular and cellular mechanisms of PG and IBD co-development are currently unknown, hampering the development of effective treatment strategies for individuals affected by both diseases.

In this talk I will:

• Highlight a clinical study looking at the role of neutrophil extracellular traps (NETs) in inflammation
• Showcase the first experimental murine model of PG and IBD

***Note Dr. Jatana is a 2016 University of Rochester Alumnus***

Hosted by UR Dermatology.